A Spectrum of Dynamic Insulin Sensitivity Test Protocols
نویسندگان
چکیده
منابع مشابه
A spectrum of dynamic insulin sensitivity test protocols.
BACKGROUND Numerous tests have been developed to estimate insulin sensitivity (SI). However, most of the established tests are either too expensive for widespread application or do not yield reliable results. The dynamic insulin sensitivity and secretion test (DISST) uses assays of glucose, insulin, and C-peptide from nine samples to quantify SI and endogenous insulin secretion (UN) at a compar...
متن کاملThe Identification of Insulin Saturation Effects During the Dynamic Insulin Sensitivity Test
BACKGROUND Many insulin sensitivity (SI) tests identify a sensitivity metric that is proportional to the total available insulin and measured glucose disposal despite general acceptance that insulin action is saturable. Accounting for insulin action saturation may aid inter-participant and/or inter-test comparisons of insulin efficiency, and model-based glycaemic regulation. METHOD Eighteen s...
متن کاملModeled Insulin Sensitivity and Interstitial Insulin Action from a Pilot Study of Dynamic Insulin Sensitivity Tests
An accurate test for insulin resistance can delay or prevent the development of Type 2 diabetes and its complications. The current gold standard test, CLAMP, is too labor intensive to be used in general practice. A recently developed dynamic insulin sensitivity test, DIST, uses a glucose-insulin-C-peptide model to calculate model-based insulin sensitivity, SI . Preliminary results show good cor...
متن کاملDynamic insulin on board: incorporation of circadian insulin sensitivity variation.
BACKGROUND Insulin-on-board (IOB) estimation is used in modern insulin therapy with continuous subcutaneous insulin infusion (CSII) as well as different automatic glucose-regulating strategies (i.e., artificial pancreas products) to prevent insulin stacking that may lead to hypoglycemia. However, most of the IOB calculations are static IOB (sIOB): they are based only on approximated insulin dec...
متن کاملDesign and clinical pilot testing of the model-based dynamic insulin sensitivity and secretion test (DISST).
BACKGROUND Insulin resistance is a significant risk factor in the pathogenesis of type 2 diabetes. This article presents pilot study results of the dynamic insulin sensitivity and secretion test (DISST), a high-resolution, low-intensity test to diagnose insulin sensitivity (IS) and characterize pancreatic insulin secretion in response to a (small) glucose challenge. This pilot study examines th...
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ژورنال
عنوان ژورنال: Journal of Diabetes Science and Technology
سال: 2011
ISSN: 1932-2968,1932-2968
DOI: 10.1177/193229681100500626